GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs853679 | 1 | rs10456362 | chr6:28221816 | ZNF323 | chr6:28292517-28324048:- | -0.21 | -3.87 | 0.000113 | Depression |
| BRCA | cis | rs853679 | 1 | rs10456362 | chr6:28221816 | ZNF389 | chr6:28129551-28137375:+ | 0.18 | 3.48 | 0.000528 | Depression |
| BRCA | cis | rs2274459 | 1 | rs10456420 | chr6:33754301 | IP6K3 | chr6:33689443-33714762:- | 0.28 | 4.89 | 1.16E-6 | Obesity (extreme) |
| BRCA | cis | rs9473555 | 1 | rs10456622 | chr6:49396453 | CENPQ | chr6:49431096-49460820:+ | -0.19 | -6.17 | 9.68E-10 | Folate pathway vitamin levels |
| BRCA | cis | rs9473555 | 1 | rs10456622 | chr6:49396453 | MUT | chr6:49398994-49431031:- | 0.36 | 11.19 | 1.43E-27 | Folate pathway vitamin levels |
| BRCA | cis | rs12524865 | 1 | rs10457618 | chr6:134188626 | TCF21 | chr6:134210259-134219157:+ | 0.16 | 4.27 | 2.08E-5 | Coronary heart disease |
| BRCA | cis | rs11174436 | 1 | rs10459253 | chr12:62707134 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.63 | 0.000301 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs10459256 | chr12:62812438 | FAM19A2 | chr12:62102043-62653925:- | 0.16 | 3.51 | 0.000462 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs2337406 | 1 | rs10459466 | chr14:107145272 | LOC100133469 | chr14:106938455-106951529:+ | 0.16 | 3.49 | 0.0005 | Alzheimer's disease (late onset) |
| BRCA | cis | rs7267979 | 1 | rs1046073 | chr20:25281333 | FAM182A | chr20:26035250-26067552:+ | -0.2 | -5.4 | 8.27E-8 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs1046073 | chr20:25281333 | FAM182B | chr20:25744102-25848786:- | 0.23 | 5.94 | 3.95E-9 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs10461617 | 1 | rs10461617 | chr5:56104308 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 19.67 | 9.17E-74 | Type 2 diabetes |
| BRCA | cis | rs10463316 | 1 | rs10463316 | chr5:150746034 | SLC36A1 | chr5:150816553-150871939:+ | 0.11 | 3.94 | 8.55E-5 | Metabolite levels (Pyroglutamine) |
| BRCA | cis | rs7515577 | 1 | rs10465756 | chr1:93029698 | EVI5 | chr1:92974255-93257961:- | -0.18 | -5.04 | 5.37E-7 | Cholesterol, total |
| BRCA | cis | rs111803315 | 1 | rs1046701 | chr14:59939804 | C14orf149 | chr14:59939406-59951126:- | 0.29 | 4.69 | 3.06E-6 | Schizophrenia |